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WorldVolodymyr Zelenskyy warned a surge in Ukrainian drones in Russia's skies meant Russian airspace would be "effectively" closed. Meanwhile, Russian drones have hit Kyiv for a seventh straight day. Follow DW for more.
ScienceMinimal cells offer a platform to uncover the fundamental physicochemical principles of cellular life. While genomes, proteomes, and metabolic networks of cells have been elucidated, the lipidome, which determines the physicochemical identity of the membrane, remains only partially characterized. Yet, the membrane is a central determinant of cellular viability, regulating solute permeability, mechanical stability, and environmental cues. Here, we investigate membranes that recapitulate the lipid composition of the minimal cell JCVI-syn3A, which is distinguished by an unusually high cholesterol content and simple composition. Combining cryo-electron microscopy, Langmuir monolayer experiments, permeability assays, and coarse-grained molecular dynamics simulations, we demonstrate that cholesterol and sphingomyelin act as dominant condensing agents that stabilize the membrane while preserving an ordered yet fluid state. These lipids enhance lipid packing and acyl-chain order, whereas cardiolipin, POPC, and DOPG counterbalance condensation by promoting fluidity and compressibility. Cholesterol–sphingomyelin interactions emerge as a key thermodynamic driver that fine-tunes membrane order, fluidity, and permeability. Remarkably, membranes containing up to 60 mol% of cholesterol remain permeable to water and physiologically relevant osmolytes at rates compatible with growth of JCVI-syn3A. Together, our results define the physicochemical principles underlying minimal cell membranes and reveal how lipid composition enables passive permeation while maintaining membrane integrity. JCVI-syn3A, a model of minimal cellular life, relies on a cholesterol-rich membrane whose properties remain poorly understood. Here, authors show how cholesterol and sphingomyelin balance membrane order, fluidity, permeability, and mechanical stability to support minimal cell function.
BusinessAcumen Pharmaceuticals, Inc. a clinical-stage biopharmaceutical company developing novel therapeutics that target toxic soluble amyloid beta oligomers for the treatment of Alzheimer’s disease, announced today that management will participate in the following upcoming investor conferences. Cantor Global Healthcare Conference 2026 DateTime: Fireside chat on Wednesday, September 9, 2026 at 3:55 p.m. ET Citi’s 2026 ...
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